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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

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Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
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Controlled release using mesoporous materials containing gate-like scaffoldings.

Elena Aznar1, Ramón Martínez-Máñez, Félix Sancenón

  • 1Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro mixtoUniversidad Politécnica de Valencia-Universidad de Valencia, Spain.

Expert Opinion on Drug Delivery
|June 13, 2009
PubMed
Summary
This summary is machine-generated.

Gated mesoporous silica solids offer controlled release of substances. These materials feature tunable pores and large surface areas, enabling triggered cargo release for potential drug delivery applications.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Mesoporous silica materials possess tunable pore sizes (2-10 nm) and high surface areas (up to 1200 m²/g).
  • These properties make them attractive for high-capacity loading and controlled release applications.

Purpose of the Study:

  • To review the use of gated mesoporous silica solids for controlled-release protocols.
  • To discuss the potential applications of these materials in drug delivery.

Main Methods:

  • Preparation of mesoporous silica supports with tailored pore sizes.
  • Functionalization of the external surface with gate-like systems for triggered release.
  • Investigation of various stimuli-responsive release mechanisms.

Main Results:

  • Gated mesoporous silica solids demonstrate significant potential for controlled cargo release.
  • Release can be triggered by external stimuli such as light, redox reactions, pH, temperature, polarity, and enzymes.
  • The materials exhibit a large load capacity due to their high specific surface area.

Conclusions:

  • Gated mesoporous silica solids are versatile platforms for controlled-release systems.
  • The ability to tune pore size and implement stimuli-responsive gates enhances their utility.
  • These materials hold promise for advanced drug delivery applications.