Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Defense Mechanism Against Infection

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...

Antimicrobial Proteins

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...

Functions of the Lymphatic and Immune System

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

Introduction to Lymphatic and Immune System

Introduction to Lymphatic and Immune System

Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...

Microbiota Modulation by Antibiotics

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Human Lactoferrin Synergizes with Etoposide to Inhibit Lung Adenocarcinoma Cell Growth While Attenuating Etoposide-Mediated Cytotoxicity of Human Endothelial Cells.

Biomedicines·2022

Same author

A cytotoxic effect of human lactoferrin fusion with Fc domain of IgG.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2022

Same author

Modulation of TDM-induced granuloma pathology by human lactoferrin: a persistent effect in mice.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2022

Same author

Recombinant Human Lactoferrin Reduces Inflammation and Increases Fluoroquinolone Penetration to Primary Granulomas During Mycobacterial Infection of C57Bl/6 Mice.

Archivum immunologiae et therapiae experimentalis·2022

Same author

A Novel Human Recombinant Lactoferrin Inhibits Lung Adenocarcinoma Cell Growth and Migration with No Cytotoxic Effect on Normal Human Epithelial Cells.

Archivum immunologiae et therapiae experimentalis·2021

Same author

Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease.

NPJ vaccines·2021

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

Lactoferrin as a natural immune modulator.

Jeffrey K Actor¹, Shen-An Hwang, Marian L Kruzel

¹Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, TX 77030, USA. Jeffrey.K.Actor@uth.tmc.edu

Current Pharmaceutical Design

|June 13, 2009

Summary

Lactoferrin, an iron-binding glycoprotein, bridges innate and adaptive immunity. This review explores its role in immune homeostasis, particularly in response to infection, trauma, and injury, for therapeutic potential.

More Related Videos

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

Related Experiment Videos

Last Updated: Jun 22, 2026

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus

Published on: October 1, 2015

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

Area of Science:

Immunology
Biochemistry

Background:

Lactoferrin is an iron-binding glycoprotein crucial for mammalian immune function.
It acts as a mediator between innate and adaptive immunity.
Lactoferrin influences antigen-presenting cells and T-helper cell polarization.

Purpose of the Study:

To review current research on lactoferrin's role in immune homeostasis.
To examine lactoferrin's function as a mediator in immune responses to infection, trauma, and injury.

Main Methods:

Literature review of existing research on lactoferrin.
Analysis of lactoferrin's immunomodulatory effects.

Main Results:

Lactoferrin plays a key role in maintaining immune balance.
It modulates immune responses against pathogens and tissue damage.
Its pleiotropic nature impacts various immune cell functions.

Conclusions:

Lactoferrin is vital for immune homeostasis and response to diverse challenges.
Understanding lactoferrin's mechanisms is critical for developing new prophylactic and therapeutic strategies.
Further research can elucidate lactoferrin's precise role in health and disease states.