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Protein engineering of a fibroblast growth factor 2 protein for targeting to bone mineral hydroxyapatite
1Department of Biochemistry, Inha University School of Medicine, Incheon, Korea.
Protein and Peptide Letters
|June 13, 2009
Abstract:
The engineering of a novel FGF2 fused with highly conserved bone mineral-binding domain of osteocalcin (OC) for targeting to bone mineral hydroxyapatite (HA) exhibited much stronger HA-binding affinity than native FGF2. FGF2-OC also showed a significant increase of mitogenic activity and cellular differentiation of osteoblastic cells compared with native FGF2.

