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Association between human herpesvirus 6 and occurrence of multiple sclerosis among Jordanian patients

M Ahram1, A El-Omar, Y Baho

  • 1Department of Pharmacology and Physiology, Faculty of Medicine, Mu'tah University, PO Box 7, Mu'tah, Karak 61710, Jordan. dr.ahram@gmail.com

Acta Neurologica Scandinavica
|June 13, 2009
PubMed
Abstract

Insights

Human herpesvirus 6 (HHV-6) DNA was not significantly associated with multiple sclerosis (MS) in Jordanian patients. This study found no link between HHV-6 in serum or cerebrospinal fluid and MS prevalence or characteristics.

Area of Science:

  • Neuroimmunology
  • Virology
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is an autoimmune disease potentially triggered by infectious agents.
  • Human herpesvirus 6 (HHV-6) has been implicated as a possible causative agent in MS.
  • Limited research exists on MS and HHV-6 prevalence in Jordan.

Purpose of the Study:

  • To investigate the prevalence of HHV-6 in Jordanian MS patients.
  • To determine the association between HHV-6 and MS in this population.
  • To explore potential links between HHV-6 and MS clinical characteristics.

Main Methods:

  • Nested polymerase chain reaction (PCR) was used for enhanced sensitivity.
  • HHV-6 DNA was detected in serum and cerebrospinal fluid (CSF) samples.
  • 36 MS patients and control individuals were analyzed.

Main Results:

  • HHV-6 DNA was detected in 26% of MS patient serum samples, with no significant difference compared to controls.
  • No association was found between MS and HHV-6 DNA presence in CSF samples.
  • No correlation was identified between HHV-6 and MS in terms of gender, diagnosis type, symptoms, or disease score in Jordanian patients.

Conclusions:

  • The study found no apparent association between HHV-6 and MS in the Jordanian patient cohort.
  • Genetic polymorphism and geographical distribution of MS and pathogens may influence findings.
  • Further research is needed to explore these potential factors.

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