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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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Related Experiment Video

Updated: Jun 22, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Central hyperthermia in acute stroke.

Chung-Yang Sung1, Tsong-Hai Lee, Nai-Shin Chu

  • 1Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University School of Medicine, Taoyuan, Taiwan. sung0597@cgmh.org.tw

European Neurology
|June 13, 2009
PubMed
Summary
This summary is machine-generated.

Central hyperthermia, often following stroke, presents with rapid high fever and temperature fluctuations. This condition is linked to brainstem damage and carries a high mortality rate.

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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Area of Science:

  • Neurology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Central hyperthermia following stroke remains poorly understood.
  • This study aimed to characterize the clinical features of central hyperthermia.

Purpose of the Study:

  • To define the characteristics of central hyperthermia after stroke.
  • To identify associated stroke lesion locations and clinical features.

Main Methods:

  • Seventy-four patients with hyperthermia (>=39°C) within 24 hours of stroke onset were analyzed.
  • Lesion sites, stroke nature, and clinical features were investigated.

Main Results:

  • Brainstem hemorrhage was the most frequent cause (64%), with all cases involving brainstem damage.
  • Rapid onset (within 12h) and significant temperature fluctuations were observed.
  • High mortality (nearly 70% within 1 month) was associated with severe fever (>41°C) or rapid onset.

Conclusions:

  • Central hyperthermia is characterized by rapid onset, high fever, significant temperature fluctuations, and high mortality.
  • Brainstem damage, particularly in the pons, is strongly associated with this condition.