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Updated: Jun 22, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
UVB and UVA initiate different pathways to p53-dependent apoptosis in melanocytes
Frances P Noonan1, Edward C De Fabo
1Department of Microbiology, Immunology, and Tropical Medicine, George Washington University Medical Center, Washington, DC 20037, USA. drmfpn@gwumc.edu
Abstract:
The incidence of cutaneous malignant melanoma (CMM) has more than doubled in the past 25 years and continues to increase at over 3% per year across all age groups (Linos et al., this issue), and invasive and disseminated melanoma in young women has increased by almost 10% since 1992 (Purdue et al., 2008). Early detection and excision of CMM can result in successful treatment, but disseminated disease is resistant to current therapies and has a very poor prognosis (Garbe and Eigentler, 2007). Sunlight exposure is a major risk factor for melanoma. In this issue, Waster and llinger investigate the effects of UVB and UVA on melanocytes.
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