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Updated: Jun 22, 2026

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection
Published on: May 7, 2020
Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: report of a case successfully treated as
Kota Shimada1, Toshihiro Matsui, Misato Kawakami
1Department of Rheumatology, National Hospital Organization Sagamihara Hospital, 18-1 Sakura-dai, Sagamihara, Kanagawa, 228-8522, Japan. k-shimada@sagamihara-hosp.gr.jp
Abstract:
A case of biopsy-confirmed chronic leptomeningitis complicating rheumatoid arthritis in a 53-year old female is reported. Her symptoms included weight loss, severe depression, and pyrexia. Magnetic resonance imaging was useful in diagnosis. Intravenous methylprednisolone was prescribed (1 g/day for 3 days), followed by prednisolone (initial dose of 30 mg daily), and this treatment was effective. Her IgG-index, serum levels of soluble interleukin-2 receptor and ferritin, and cerebrospinal level of interleukin-6 paralleled her clinical course.
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