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Related Experiment Videos

Time required for oral ranitidine to decrease gastric fluid acidity.

B R Jacobs1, C A Swift, H D Dubow

  • 1Department of Anesthesiology, Yale University School of Medicine, Yale-New Haven Hospital, CT 06510.

Anesthesia and Analgesia
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

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Oral ranitidine effectively reduces gastric acidity in surgical patients. Administering ranitidine over 90 minutes before anesthesia ensures a safe pH level, preventing acid production.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Gastroenterology

Background:

  • Gastric fluid acidity is a critical factor in aspiration risk during surgery.
  • Previous studies have not fully delineated the effects of ranitidine within a short dose-to-sampling interval.
  • Understanding ranitidine's impact on gastric pH is crucial for perioperative management.

Purpose of the Study:

  • To document gastric fluid acidity in ambulatory surgical patients after a single oral dose of ranitidine.
  • To delineate the specific changes in gastric pH within a 30-120 minute post-dosing interval.
  • To assess the efficacy of ranitidine in preventing gastric acid production before anesthesia induction.

Main Methods:

  • A study involving 112 adult patients (ASA physical status I-III) undergoing outpatient surgery.

Related Experiment Videos

  • Patients received a 300-mg oral tablet of ranitidine with 15 mL of water.
  • Gastric fluid was aspirated after anesthesia induction, and its volume and pH were analyzed and compared to a reference group.

    • Main Results:

    • Within 30-60 minutes post-dosing, 26 out of 40 patients achieved a gastric pH >= 2.5 (mean pH 3.9 +/- 2).
    • Beyond 90 minutes, all 28 patients sampled had a gastric pH >= 2.5 (mean pH 6.3 +/- 1).
    • No significant differences in mean gastric volume were observed between groups.

    Conclusions:

    • Oral ranitidine consistently prevents gastric acid production when administered more than 90 minutes before anesthesia induction in patients without increased aspiration risk factors.
    • Ranitidine is effective in raising gastric pH to a safer level for ambulatory surgery.
    • The timing of ranitidine administration is a key factor in its efficacy for managing gastric acidity.