Related Experiment Video
Updated: Jun 22, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Synthesis and antimalarial activities of optically active labdane-type diterpenes
José Villamizar1, Jean P Pittelaud, Juan R Rodrigues
1Centro de Química, Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas 1020-A, Venezuela. jvillami@ivic.ve
Abstract:
An efficient method for the synthesis of optically active labdane-type diterpenes from (+)-manool 8 is described. We prepared the natural labdane-type diterpene 5 via key intermediate peroxide 9, and synthetic hydroxybutenolides 6 and 7 via a furan photosensitised oxygenation reaction of labdafuran (14). Compounds 5, 6, 7 and 9 were evaluated as inhibitors of the beta-haematin formation and globin proteolysis, and then were assayed in a malarial murine model. Compound 9 was the most promising compound, showing a positive correlation between in vitro and in vivo activities.
More Related Videos
12:02An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
07:12Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Related Concept Videos
Antiprotozoal Agents
Antifungal Agents
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Aryldiazonium Salts to Azo Dyes: Diazo Coupling