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Prevalence of myocardial infarction in patients with psoriasis in central China

J Xiao1, L-H Chen, Y-T Tu

  • 1Department of Dermatology, Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of the European Academy of Dermatology and Venereology : JEADV
|June 16, 2009
PubMed

Insights

Myocardial infarction (MI) prevalence is higher in patients with mild and severe psoriasis compared to those without the condition in central China. Cardiovascular risk factors are also significantly associated with psoriasis.

Area of Science:

  • Cardiology
  • Dermatology
  • Epidemiology

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Cardiovascular disease is a leading cause of mortality worldwide.
  • The link between psoriasis and cardiovascular risk factors requires further investigation.

Purpose of the Study:

  • To determine if myocardial infarction (MI) prevalence is higher in patients with psoriasis compared to controls.
  • To investigate the association between major cardiovascular risk factors and psoriasis in central China.

Main Methods:

  • A case-control study was conducted using data from four hospitals in central China between 1999 and 2007.
  • Patients with psoriasis were classified as mild or severe based on treatment.
  • Cardiovascular risk factors included diabetes, hypertension, hyperlipidemia, and smoking.
  • Conditional logistic regression was used for analysis, adjusting for age and sex.

Main Results:

  • MI prevalence was 6.00% in mild psoriasis and 8.01% in severe psoriasis, compared to 2.96% in controls.
  • Patients with mild and severe psoriasis showed significantly higher odds of obesity, diabetes, hypertension, hyperlipidemia, and smoking.
  • After adjustments, patients with mild or severe psoriasis had increased odds of MI (OR=1.72 and 2.01, respectively).

Conclusions:

  • The prevalence of MI is elevated in both mild and severe psoriasis patients in central China.
  • Major cardiovascular risk factors are significantly associated with psoriasis in this population.
  • These findings highlight the importance of cardiovascular risk assessment in patients with psoriasis.
Abstract

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