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Updated: Jun 22, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Pregnancy outcome in women with factor V Leiden and recurrent miscarriage
S Jivraj1, M Makris, S Saravelos
1Department of Obstetrics & Gynaecology, Jessop Wing, Sheffield, UK. sjivraj007@aol.com
Abstract:
We compared the outcome of 25 untreated pregnancies among women with recurrent miscarriage (RM) at <12 weeks' gestation who were heterozygous for factor V Leiden with women with unexplained RM. The livebirth rate was lower among pregnancies in carriers of factor V Leiden (12/25; 48%) compared with pregnancies in women with unexplained RM (175/307; 57%), but the difference did not reach statistical significance. The best possible treatment regimen to improve livebirth rate in this group of women needs to be assessed in the form of a randomised controlled trial.
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