Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Transgenic Organisms

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Hybridoma Technology

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...

Plant Breeding and Biotechnology

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.

Transgenic Plants

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

MIXed plastics biodegradation and UPcycling using microbial communities: EU Horizon 2020 project MIX-UP started January 2020.

Environmental sciences Europe·2021

Same author

Growing a circular economy with fungal biotechnology: a white paper.

Fungal biology and biotechnology·2020

Same author

KnowVolution of a Fungal Laccase toward Alkaline pH.

Chembiochem : a European journal of chemical biology·2019

Same author

The putative H3K36 demethylase BcKDM1 affects virulence, stress responses and photomorphogenesis in Botrytis cinerea.

Fungal genetics and biology : FG & B·2018

Same author

Manipulation of cytokinin level in the ergot fungus Claviceps purpurea emphasizes its contribution to virulence.

Current genetics·2018

Same author

Identification and characterization of the ergochrome gene cluster in the plant pathogenic fungus <i>Claviceps purpurea</i>.

Fungal biology and biotechnology·2017

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Generation and Genetic Manipulation of Human Cervical Organoids

Generation and Genetic Manipulation of Human Cervical Organoids

Published on: March 10, 2026

Ergot: from witchcraft to biotechnology.

Thomas Haarmann¹, Yvonne Rolke, Sabine Giesbert

¹Institut für Botanik, Westf. Wilhelms-Universität Münster, Germany.

Molecular Plant Pathology

|June 16, 2009

Summary

Claviceps fungi cause ergot diseases in grasses, impacting agriculture and history. Advances in molecular genetics enhance understanding of ergot alkaloid production and pathogen control for potential new medicines.

More Related Videos

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

Optimization and Utilization of Agrobacterium-mediated Transient Protein Production in Nicotiana

Optimization and Utilization of Agrobacterium-mediated Transient Protein Production in Nicotiana

Published on: April 19, 2014

Related Experiment Videos

Last Updated: Jun 22, 2026

Generation and Genetic Manipulation of Human Cervical Organoids

Generation and Genetic Manipulation of Human Cervical Organoids

Published on: March 10, 2026

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

Optimization and Utilization of Agrobacterium-mediated Transient Protein Production in Nicotiana

Optimization and Utilization of Agrobacterium-mediated Transient Protein Production in Nicotiana

Published on: April 19, 2014

Area of Science:

Agricultural Science
Mycology
Biotechnology

Background:

Ergot diseases, caused by Claviceps fungi, have historically devastated agriculture and caused epidemics.
Ergot alkaloids, produced by Claviceps, have pharmaceutical applications but also toxicity concerns.
Claviceps is a significant global pathogen and a source of novel therapeutic compounds.

Purpose of the Study:

To explore the molecular genetics of ergot alkaloid biosynthesis in Claviceps.
To understand the infection strategies of Claviceps as a biotrophic pathogen.
To identify opportunities for improving in vitro production of ergot alkaloids and developing new drug candidates.

Main Methods:

Utilizing molecular genetics to investigate the genetic basis of alkaloid synthesis.
Analyzing the infection mechanisms of the Claviceps pathogen.
Developing and optimizing biotechnological processes for in vitro alkaloid production.

Main Results:

Detailed insights into the genetic pathways of ergot alkaloid biosynthesis.
Elucidation of the sophisticated infection strategy employed by Claviceps.
Development of efficient biotechnological methods for in vitro production of ergot alkaloids.

Conclusions:

Molecular genetics provides a powerful tool for understanding and manipulating Claviceps.
Improved knowledge facilitates the design of novel alkaloids and enhanced production strains.
Claviceps remains a crucial pathogen and a promising source for new drugs targeting central nervous system diseases.