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Updated: Jun 22, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Toward a transdisciplinary model of evidence-based practice
Jason M Satterfield1, Bonnie Spring, Ross C Brownson
1Division of General Internal Medicine, University of California, 400 Parnassus Ave, A-405, San Francisco, CA 94143-0320, USA. jsatter@medicine.ucsf.edu
This study proposes a unified, transdisciplinary evidence-based practice (EBP) model to address challenges in defining evidence, incorporating patient context, and clarifying expert roles across health disciplines.
Area of Science:
- Health Sciences
- Interdisciplinary Studies
Background:
- Traces the historical development and current state of evidence-based practice (EBP) across medicine, nursing, psychology, social work, and public health.
- Examines the evolution of the 'three circles' model of evidence-based medicine.
Purpose of the Study:
- To identify and compare core issues and challenges in EBP across various health disciplines.
- To present a unified, transdisciplinary EBP model that integrates strengths and mitigates weaknesses from existing disciplinary models.
Main Methods:
- Comparative analysis of EBP models across diverse health disciplines.
- Development of a novel, unified transdisciplinary EBP model.
Main Results:
- Identified common EBP challenges: defining and weighting evidence, integrating patient/contextual factors, defining the expert role, and considering additional variables (age, social class, resources).
Conclusions:
- A unified transdisciplinary EBP model can overcome historical limitations by redefining model components, clarifying practitioner expertise, emphasizing shared decision-making, and incorporating environmental/organizational contexts.
- Discusses implications for academia, practice, and policy.
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