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Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

Glioblastoma multiforme.

Mary Welch1, Rose Lai

  • 1Rose Lai, MD, MSc The Neurological Institute of Columbia University, 710 West 168th Street, Room 204, New York, NY 10032, USA. RLai@neuro.columbia.edu.

Current Treatment Options in Neurology
|June 16, 2009
PubMed
Summary

Newly diagnosed glioblastoma multiforme treatment involves surgery, radiation, and temozolomide. Ongoing trials explore new therapies for improved survival, with bevacizumab used for recurrence.

Area of Science:

  • Neuro-oncology
  • Radiation Oncology
  • Medical Oncology

Background:

  • Glioblastoma multiforme (GBM) is an aggressive primary brain tumor.
  • Standard treatment involves maximal surgical resection, radiation, and temozolomide.
  • Further therapeutic advancements are needed to improve patient survival.

Purpose of the Study:

  • To outline the current optimal management of newly diagnosed glioblastoma multiforme.
  • To highlight ongoing research for enhanced treatment strategies.
  • To discuss therapeutic options for recurrent disease.

Main Methods:

  • Review of standard treatment protocols for glioblastoma multiforme.
  • Discussion of current phase 3 clinical trials investigating novel therapeutic agents.

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  • Overview of treatment approaches for recurrent glioblastoma.

    • Main Results:

    • The established regimen includes surgery, radiation (60 Gy), and temozolomide (concomitant and maintenance).
    • Multiple phase 3 trials are evaluating additional agents for survival benefit.
    • Bevacizumab is a common choice for recurrent glioblastoma.

    Conclusions:

    • Optimal management of newly diagnosed glioblastoma requires a multimodal approach.
    • Clinical trials focusing on antiangiogenic and targeted therapies are crucial for future progress.
    • Patient participation in clinical trials is highly encouraged.