Related Experiment Video
Updated: Jun 22, 2026

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
Published on: April 7, 2023
Duration of progesterone-in-oil support after in vitro fertilization and embryo transfer: a randomized, controlled
Christine S Goudge1, Theodore C Nagel, Mark A Damario
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota 55454, USA.
Objective:
To determine the efficacy of a short P-in-oil protocol (11 days) in comparison with a traditional P-in-oil protocol (6 weeks) after IVF and embryo transfer.
Design:
Prospective randomized, controlled trial.
Setting:
Tertiary referral reproductive medicine unit.
Patient(S):
The first IVF-embryo transfer cycle of women
Intervention(S):
Either the standard protocol, 50 mg of IM P-in-oil daily for 6 weeks (group 1) or the study protocol, 50 mg of IM P-in-oil daily for 11 days (group 2).
Main Outcome Measure(S):
Clinical pregnancy, ongoing pregnancy, and live birth rates.
Result(S):
One hundred one patients were enrolled (48 in group 1, 53 in group 2). Mean age (31.8 years vs. 32.7 years) and reasons for infertility were not different between the groups. Despite higher embryo quality in group 1 than in group 2 (60.3 vs. 51.6), clinical (63.0% vs. 62.7%) and ongoing (58.7% vs. 51.0%) pregnancy rates (PR) were not significantly different. Live birth rates (52.2% vs. 49.0%) were not significantly different.
Conclusion(S):
Pregnancy and live birth rates were not different between the two groups, suggesting that the common practice of lengthy (>or=6 weeks) P support of IVF pregnancies may be unnecessary.
Related Concept Videos
In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
Intrauterine Drug Delivery Systems
Ovarian Cycle

