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Comparative assessment of Helicobacter pylori colonization in children tonsillar tissues

Yalda Jabbari Moghaddam1, Mandana Rafeey, Reza Radfar

  • 1Liver and Gastrointestinal Research Center, Tabriz University (Medical Sciences), Iran.

International Journal of Pediatric Otorhinolaryngology
|June 16, 2009
PubMed

Insights

The rapid urease test (RUT) is not sensitive enough to detect Helicobacter pylori in children

Area of Science:

  • Pediatric infectious diseases
  • Gastroenterology
  • Microbiology

Background:

  • Helicobacter pylori (H. pylori) infection is prevalent in children.
  • The tonsils may serve as a reservoir for H. pylori.

Purpose of the Study:

  • To evaluate the efficacy of the rapid urease test (RUT) for diagnosing H. pylori in pediatric tonsillar tissues.
  • To determine the presence of H. pylori in tonsillar tissue of children.

Main Methods:

  • Prospective clinical study involving 285 children aged 4-14 years.
  • Tonsillar tissue samples were tested using RUT and histopathologic biopsy.
  • Serum IgG H. pylori levels were measured simultaneously.

Main Results:

  • H. pylori was detected in 39.6% of children via histopathology.
  • Only 14% of patients had a positive RUT result.
  • Histopathology and RUT showed positive results concurrently in 40 patients.

Conclusions:

  • H. pylori is present in the tonsillar tissues of children.
  • The rapid urease test (RUT) demonstrates low sensitivity for diagnosing H. pylori in tonsillar tissue.
  • Tonsils may play a role in H. pylori reservoirs in pediatric populations.
Abstract

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