Related Experiment Video

Updated: Jun 22, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

Interplay between Numb and Notch in epithelial cancers: role for dual oxidase maturation factor

E A Ostrakhovitch1

  • 1Department of Chemistry, University of Western Ontario, London, Ontario, Canada. eostrakh@uwo.ca

European Journal of Cancer (Oxford, England : 1990)
|June 16, 2009
PubMed

Insights

Numb and Notch signalling pathways regulate cell fate. An imbalance is linked to cancer progression. Numb-interacting protein (NIP) may coordinate this network in epithelial cancers.

Area of Science:

  • Cellular biology
  • Molecular biology
  • Cancer research

Background:

  • Numb and Notch signalling pathways are crucial for cell fate and differentiation.
  • Their opposing effects maintain a balance critical for normal development.
  • Dysregulation of this balance is implicated in epithelial cancers, affecting progression and metastasis.

Purpose of the Study:

  • To examine the potential link between Numb, Notch, and Dual oxidase maturation factor (NIP) in epithelial cancers.
  • To understand how NIP influences the Numb/Notch network.

Main Methods:

  • The study focuses on the interaction between Numb, Notch, and NIP.
  • It investigates the role of NIP in promoting the translocation of Numb and DUOX proteins.

Main Results:

  • Numb-interacting protein (NIP), also known as dual oxidase maturation factor, associates with Numb and DUOX.
  • NIP promotes the translocation of Numb and DUOX, suggesting a role in coordinating the Numb/Notch network.

Conclusions:

  • NIP may play a key role in coordinating the Numb/Notch signalling network within epithelial cancers.
  • Understanding this interaction could offer new insights into cancer biology and therapeutic strategies.

More Related Videos

Stimulation of Notch Signaling in Mouse Osteoclast Precursors08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...