Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of the Female Reproductive System

Disorders of the Female Reproductive System

The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: 5-HT₃ Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

Other Disorders of Digestive System

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Charge acceleration without radiation.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Defining Standard Data Reporting in Pelvic Exenterations for Non-Rectal Cancers: A Systematic Review of Current Data Reporting.

Cancers·2025

Same author

Survival outcomes in patients with sigmoid volvulus.

International journal of colorectal disease·2025

Same author

Corrigendum to 'The Impact of Delayed Processing of Chilled Whole Blood Specimens on the Measurement of Nutritional Biomarkers in the United Kingdom National Diet and Nutrition Survey Rolling Programme',[J Nutr 154 (2024) 2818-2826].

The Journal of nutrition·2025

Same author

Plan quality assessment of modern radiosurgery technologies in the treatment of multiple brain metastases.

Biomedical physics & engineering express·2024

Same author

Erratum to: Glutamine preconditioning protects against local and systemic injury induced by orthopaedic surgery.

The journal of nutrition, health & aging·2024

Same journal

Blood-Based MicroRNAs as Biomarkers of Insulin Resistance in Childhood Obesity: A Systematic Review and meta-analysis.

Molecular and cellular endocrinology·2026

Same journal

Female-specific metabolic genetic liability reveals a separable metabolic dimension of polycystic ovary syndrome.

Molecular and cellular endocrinology·2026

Same journal

The kisspeptin analog C6 elicits greater tachyphylaxis and transcriptional activation than kisspeptin-10 and -54.

Molecular and cellular endocrinology·2026

Same journal

G1 regulation of BK<sub>Ca</sub> channel leads to decreased migration of senescent pericytes and improved age-related hearing loss.

Molecular and cellular endocrinology·2026

Same journal

Maternal butyrate administration ameliorates fetal fatty liver and maternal metabolic alterations related to maternal obesity.

Molecular and cellular endocrinology·2026

Same journal

Retraction notice to " Steroid-induced oocyte maturation in Indian shad Tenualosa ilisha (Hamilton, 1822) is dependent on phosphatidylinositol 3 kinase but not MAP kinase activation" [Mol. Endocrinol. 390 (2014) 26-33].

Molecular and cellular endocrinology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

Estrogen and gastrointestinal malignancy.

A M Hogan¹, D Collins, A W Baird

¹Institute for Clinical Outcomes Research and Education (iCORE), St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland. Aislinghogan@yahoo.com

Molecular and Cellular Endocrinology

|June 16, 2009

Summary

This summary is machine-generated.

Estrogen (E2) impacts the gastrointestinal tract, with significant evidence suggesting a protective role against colon cancer development and proliferation. Further research into estrogen

More Related Videos

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jun 22, 2026

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

Published on: January 26, 2024

Area of Science:

Endocrinology
Gastroenterology
Oncology

Background:

Estrogen's (E2) effects on the gastrointestinal tract have been studied for decades.
Existing research presents a complex and often contradictory picture of its role in various gastrointestinal cancers.
The full impact of this steroid hormone remains incompletely understood.

Purpose of the Study:

To consolidate existing research on estrogen's role in gastrointestinal tract function and disease.
To highlight the most promising areas of investigation, particularly in colon cancer.
To explore the mechanisms underlying estrogen's effects on the gastrointestinal system.

Main Methods:

Review and synthesis of existing scientific literature on estrogen and gastrointestinal health.
Analysis of studies investigating estrogen's role in esophageal, gastric, gallbladder, and colon cancers.
Examination of proposed mechanisms of action for estrogen's effects.

Main Results:

Evidence for estrogen's role in esophageal, gastric, and gallbladder cancers is equivocal.
Strongest evidence indicates a protective effect of estrogen (potentially ERbeta) against colon cancer development and proliferation.
Multiple mechanisms underlying estrogen's action in colon cancer have been identified.

Conclusions:

Estrogen plays a significant, though not fully understood, role in gastrointestinal function.
Estrogen demonstrates a clear protective potential against colon cancer.
Hormonal manipulation may become a key component of future colon cancer management strategies.