Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bronchial responsiveness and lung function in recurrently wheezy infants.

S M Stick1, J Arnott, D J Turner

  • 1Department of Respiratory Medicine, University of Western Australia, Perth.

The American Review of Respiratory Disease
|November 1, 1991
PubMed
Summary

Wheezy infants show lower baseline airflow but do not exhibit increased bronchial responsiveness (BR) to histamine compared to healthy infants. This suggests different underlying mechanisms for infant wheezing versus childhood asthma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The association of peri-operative scores, including frailty, with outcomes after unscheduled surgery.

Anaesthesia·2018
Same author

Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2018
Same author

Impaired airway epithelial cell responses from children with asthma to rhinoviral infection.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
Same author

Overexpression of miR-214-3p in esophageal squamous cancer cells enhances sensitivity to cisplatin by targeting survivin directly and indirectly through CUG-BP1.

Oncogene·2015
Same author

Physiotherapy and lung disease in children.

The Australian journal of physiotherapy·2014
Same author

Feasibility of parental collected nasal swabs for virus detection in young children with cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2014

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Allergy and Immunology

Background:

  • Infant wheezing is common but often unresponsive to asthma treatments.
  • Pathologic mechanisms causing wheezing in infants remain poorly understood.
  • The link between wheezing and bronchial responsiveness (BR) in older individuals is well-established.

Purpose of the Study:

  • To investigate if the association between wheezing and BR observed in older subjects is also present in infants.
  • To compare bronchial responsiveness to inhaled histamine in wheezy infants versus healthy controls.

Main Methods:

  • Study included 19 recurrently wheezy infants and age-, height-, weight-, and sex-matched controls.
  • Bronchial responsiveness (BR) assessed using inhaled histamine challenge.

Related Experiment Videos

  • Maximal flow at functional residual capacity (VmaxFRC) measured via partial expiratory flow-volume curves; PC40 (provocative concentration causing 40% fall in VmaxFRC) determined.

    • Main Results:

    • Wheezy infants had significantly lower median baseline VmaxFRC (100.0 ml/s) compared to controls (182.0 ml/s, p < 0.01).
    • No significant difference in PC40 was found between wheezy infants (2.1 g/L) and control infants (2.3 g/L).
    • This indicates similar bronchial responsiveness despite differing baseline airflow.

    Conclusions:

    • Recurrent wheezing in infants is associated with reduced baseline airflow but not increased bronchial responsiveness to histamine.
    • The findings suggest that wheezing in infancy may stem from different pathophysiological mechanisms than those in older asthmatic individuals.
    • Further research is needed to elucidate the specific mechanisms driving wheezing in this age group.