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Published on: January 21, 2019
Histopathologic and immunophenotypic profile of subglottic hemangioma: multicenter study
Arunkumar N Badi1, Joseph E Kerschner, Paula E North
1Division of Pediatric Otolaryngology, Medical College of Wisconsin, Children's Hospital of Wisconsin, 9000 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
International Journal of Pediatric Otorhinolaryngology
|June 16, 2009
Summary
Most subglottic hemangiomas (SGH) are infantile hemangiomas (IH), confirmed by GLUT-1 staining. This study highlights GLUT-1 as crucial for diagnosing SGH, differentiating them from other conditions.
Area of Science:
- Pediatric Pathology
- Vascular Anomalies
- Immunohistochemistry
Background:
- Subglottic hemangioma (SGH) is a rare childhood tumor causing airway compromise.
- Distinguishing SGH from congenital hemangiomas is critical for diagnosis and treatment.
- This study provides the largest multi-institutional analysis with immunophenotypic characterization of SGH.
Purpose of the Study:
- To immunophenotypically characterize subglottic hemangiomas (SGH).
- To determine if SGH are histologically similar to infantile hemangiomas (IH).
- To evaluate the utility of GLUT-1 staining in SGH diagnosis.
Main Methods:
- Retrieved biopsy-proven SGH samples from three children's hospitals.
- Collected demographic and clinical data.
- Performed Hematoxylin and Eosin (H&E) and GLUT-1 immunohistochemical staining.
Main Results:
- 19 SGH cases were reviewed; 18 had tissue for GLUT-1 staining.
- 16/19 specimens were histologically classical infantile hemangiomas (IH) and GLUT-1 positive.
- Two cases were non-hemangioma tissue (granulation/fibrous tissue) and GLUT-1 negative.
Conclusions:
- Most subglottic hemangiomas (SGH) are histologically and immunohistochemically infantile hemangiomas (IH).
- SGH share characteristics with IH in other locations.
- GLUT-1 immunohistochemistry is a valuable diagnostic tool for SGH.