Related Experiment Video
Updated: Jun 22, 2026
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
Early detection of local RFA site recurrence using total liver volume perfusion CT initial experience
Martijn R Meijerink1, Jan Hein T M van Waesberghe, Lineke van der Weide
1Department of Radiology, VU University Medical Center, De Boelelaan 1117, Postbus 7057 Amsterdam, The Netherlands. mr.meijerink@vumc.nl
Rationale And Objectives:
The aim of this study was to prospectively evaluate the feasibility of a novel total liver volume perfusion computed tomographic technique in demonstrating treatment-site recurrence of liver metastases after radiofrequency ablation (RFA).
Materials And Methods:
Eleven patients considered to be at increased risk for local RFA-site tumor recurrence underwent both positron emission tomography (PET) and perfusion computed tomography (CTP): a 12-phase scan of the entire liver acquired before and 11 times after contrast injection. After coregistration, blood flow maps were created using the maximum slope method.
Results:
In all cases, the CTP-derived blood flow maps fully paralleled the PET images in showing either the absence (nine of 13 lesions) or presence (four of 13 lesions) of local RFA-site recurrence. Marginal lesions with high hepatic arterial perfusion (>50 mL/min/100 g) and low portal venous perfusion (<10 mL/min/100 g) represented recurring vital tumor tissue (P < .05).
Conclusion:
Total liver volume CTP seems feasible for the detection and localization of treatment-site recurrence after RFA.
