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Updated: Jun 22, 2026

Live-Cell Forward Genetic Approach to Identify and Isolate Developmental Mutants in Chlamydia trachomatis
Published on: June 10, 2020
Baicalin suppresses expression of Chlamydia protease-like activity factor in Hep-2 cells infected by Chlamydia
Huang Hao1, Yang Aixia, Li Dan
1Center of Experimental Medicine, Wuhan No.1 Hospital, Wuhan 430022, PR China. whhuanghao10@yahoo.com.cn
Abstract:
In this study, we tested the ability of Baicalin to block Chlamydia trachomatis infection and found that the Baicalin blocked infection of Hep-2 cells. Then, we looked into the expression of RFX5 and CPAF gene in Chlamydia-infected cells. We found that RFX5 and CPAF were up-regulated and down-regulated respectively by Baicalin. Since CPAF is responsible for degrading RFX5, we suggest that CPAF was a primary target of Baicalin and played an important role in regulating RFX5. Our findings demonstrate that Baicalin can inhibit C. trachomatis effectively and therefore, can be considered as potential agents for therapy of Chlamydia infectious diseases.
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