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Updated: Jun 22, 2026

Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets
Published on: February 10, 2020
No association of DPP6 with amyotrophic lateral sclerosis in an Italian population
Isabella Fogh1, Sandra D'Alfonso, Cinzia Gellera
1MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK. I.Fogh@iop.kcl.ac.uk
Abstract:
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.

