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Updated: Jun 22, 2026

Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening
Published on: July 18, 2012
[Candida albicans endocarditis after pulmonary artery banding]
Insights
This case report details a rare instance of Candida albicans endocarditis in an infant following pulmonary artery banding. Prompt surgical intervention and antifungal treatment led to a satisfactory outcome.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
Background:
- Endocarditis is rare in infants, with Candida albicans infections being exceptionally uncommon.
- Pulmonary artery banding is a palliative procedure for congenital heart defects, sometimes used in unstable infants.
Observation:
- A 7-month-old infant, post-pulmonary artery banding for a ventricular septal defect, developed systemic Candida infection.
- Cardiac failure manifested later without typical inflammatory signs, revealing complications of the banding and pseudoaneurysm.
Findings:
- Candidal endocarditis was diagnosed, complicated by a pulmonary artery perforation due to an infected pseudoaneurysm and banding migration.
- Histopathology confirmed multisensitive Candida albicans in vegetations.
Implications:
- This case highlights the potential risks of Candida endocarditis associated with pulmonary artery banding in infants.
- Early detection and combined surgical and antifungal management are crucial for favorable outcomes in such rare pediatric cases.
Abstract:
Endocarditis is uncommon in infants and is exceptionally related to Candida albicans on pulmonary banding. We report on a case in a 7-month-old infant who had pulmonary artery banding for a ventricular septal defect and who presented with candidal endocarditis. Banding was chosen because of the patient's poor trophic and unstable status, which could be risky for surgery involving extracorporeal circulation. A few weeks after the banding, the patient developed systemic Candida infection, which was treated successfully. At 7 months, cardiac failure appeared without fever or inflammatory signs. Cardiac echography showed that the banding was not protective as well as a hyperechogenic image on the pulmonary bifurcation. The angioscan showed a hypodense thrombus. Emergency surgery was performed consisting of pulmonary artery exploration, thrombectomy, and ventricular septal defect closure. The exploration showed a pulmonary artery perforation caused by the infected pseudoaneurysm and the migration of the banding into the pulmonary artery. The anatomopathologic analysis of the vegetation identified multisensitive Candida albicans. After surgery and prolonged antifungal treatment, progression was satisfactory.
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