Related Experiment Video
Updated: Jun 22, 2026

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Dietary reference intakes for DHA and EPA
Penny M Kris-Etherton1, Jessica A Grieger, Terry D Etherton
1Department of Nutritional Sciences, The Pennsylvania State University, 319 Chandlee Laboratory, University Park, PA 16802, USA. pmk3@psu.edu
Establishing Dietary Reference Intakes (DRIs) for eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is crucial. Current US intake is low compared to global recommendations, highlighting the need for official standards for these long-chain omega-3 fatty acids.
Area of Science:
- Nutrition Science
- Dietary Guidelines
- Public Health
Background:
- Global organizations recommend eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for heart health and triglyceride reduction.
- Specific recommendations exist for DHA during pregnancy, infancy, and for vegetarians/vegans.
- The Institute of Medicine has set an Adequate Intake (AI) for alpha-linolenic acid (ALA) but not for EPA and DHA.
Purpose of the Study:
- To highlight the need for establishing Dietary Reference Intakes (DRIs) for EPA and DHA in the United States.
- To address the discrepancy between current US intake and global recommendations for long-chain omega-3 fatty acids.
- To emphasize the importance of official standards for public health policy and guidance.
Main Methods:
- Review of existing global dietary recommendations for EPA and DHA.
- Analysis of current US intake levels of EPA and DHA.
- Comparison of current US intake with established AIs and Acceptable Macronutrient Distribution Ranges (AMDRs).
Main Results:
- Current US mean intake of EPA and DHA (approx. 100mg/day) is significantly lower than many international recommendations.
- The National Academies suggest up to 10% of the ALA AMDR can be consumed as EPA/DHA, but this is not a formal DRI.
- Lack of DRIs for EPA and DHA hinders official dietary guidance and policy in the US and Canada.
Conclusions:
- There is a pressing need for the National Academies to establish DRIs for EPA and DHA.
- Establishing DRIs will provide official standards for dietary guidance and policy, promoting public health.
- Recognizing the numerous health benefits of EPA and DHA necessitates timely establishment of these crucial nutrient standards.
Related Concept Videos
Lipids: Dietary Sources and Requirements
Proteins: Dietary Sources and Requirements
Atherosclerosis III: Management
Lipid-derived Compounds in the Human Body
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
