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Circulating matrix metalloproteinase-9 concentrations and abdominal aortic aneurysm presence: a meta-analysis

Hisato Takagi1, Hideaki Manabe, Norikazu Kawai

  • 1Department of Cardiovascular Surgery, Shizuoka Medical Center, Sunto-gun, Shizuoka 411-8611, Japan.

Interactive Cardiovascular and Thoracic Surgery
|June 16, 2009
PubMed

Insights

Elevated levels of matrix metalloproteinase-9 (MMP-9) are significantly associated with the presence of abdominal aortic aneurysm (AAA). This meta-analysis confirms higher MMP-9 concentrations in AAA patients compared to controls.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Medical Diagnostics

Background:

  • Abdominal aortic aneurysm (AAA) is a life-threatening condition.
  • Matrix metalloproteinase-9 (MMP-9) is implicated in vascular remodeling and aneurysm formation.
  • Understanding biomarkers for AAA is crucial for early detection and management.

Purpose of the Study:

  • To systematically review and meta-analyze evidence on the association between circulating MMP-9 levels and AAA presence.
  • To quantify the difference in MMP-9 concentrations between AAA patients and control subjects.

Main Methods:

  • A meta-analysis of case-control studies was conducted.
  • Studies were identified through a MEDLINE database search.
  • Circulating MMP-9 concentrations were compared between AAA and control groups using standardized mean differences (SMDs).

Main Results:

  • Eight studies with 580 AAA patients and 258 controls were included.
  • Pooled analysis revealed significantly higher circulating MMP-9 concentrations in the AAA group (SMD, 0.70; 95% CI, 0.23-1.17; P=0.004).
  • Significant heterogeneity was observed across studies, but no publication bias was detected.

Conclusions:

  • Circulating MMP-9 concentrations are elevated in individuals with abdominal aortic aneurysm.
  • Higher MMP-9 levels are associated with the presence of AAA, suggesting its potential as a biomarker.

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