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Updated: Jun 22, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Arsenic trioxide associated toothache.

Jim Siderov¹, John Duggan

¹Cancer Services, Austin Health, Heidelberg, Australia. jim.siderov@austin.org.au

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners

|June 16, 2009

Summary

This summary is machine-generated.

Arsenic trioxide is generally safe for treating acute promyelocytic leukemia (APL). This report details a rare case of toothache as a potential side effect of arsenic trioxide therapy.

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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

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Microhardness Measurements on Tooth and Alveolar Bone in Rodent Oral Disease Models

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Published on: April 26, 2024

Area of Science:

Hematology
Oncology
Pharmacology

Background:

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia.
Arsenic trioxide is an effective treatment for APL, known for its safety profile and minimal side effects.
Dental toxicities are considered uncommon adverse events associated with arsenic trioxide therapy.

Observation:

A 45-year-old male patient with relapsed APL received treatment with all-trans-retinoic acid and arsenic trioxide.
The patient reported severe acute oral pain during the 6th cycle of treatment.
Comprehensive dental and orthodontic evaluations ruled out dental or endodontic causes for the pain.

Findings:

The patient's toothache resolved completely four days after completing the arsenic trioxide treatment cycle.
This case represents the first reported instance of toothache potentially linked to arsenic trioxide use in APL treatment.
The exact mechanism underlying this adverse event remains undetermined.

Implications:

Physicians should consider arsenic trioxide as a potential cause for unexplained toothache in patients undergoing APL treatment.
Further research is warranted to elucidate the mechanism of this rare dental toxicity.
This finding contributes to the comprehensive understanding of arsenic trioxide's side effect profile in APL management.