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A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting

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Myocardial dysfunction in severe falciparum malaria.

Poddutoor Preetham Kumar¹, Chirla Dinesh Kumar, Farhan A R Shaik

¹Rainbow Children's Hospital & Perinatal Centre, Banjara Hills, Hyderabad 500034, India. drpreethamp@gmail.com

Journal of Tropical Pediatrics

|June 16, 2009

Summary

This summary is machine-generated.

Severe malaria in children can cause multiorgan dysfunction. This study presents evidence of cardiac involvement and myocardial dysfunction in two pediatric cases, previously unconfirmed in children.

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Area of Science:

Pediatric Cardiology
Infectious Diseases
Cardiovascular Medicine

Background:

Severe malaria is a leading cause of mortality in children, often involving multiorgan dysfunction.
Cardiac involvement has been suspected in severe malaria, with elevated cardiac enzymes noted, but definitive echocardiographic evidence is lacking.
Previous reports of myocardial dysfunction in malaria exist for adults, but not for pediatric cases.

Observation:

This case series focuses on two children diagnosed with severe malaria.
Both children presented with clinical indicators suggestive of cardiac involvement.
Echocardiographic assessments were performed to evaluate cardiac function.

Findings:

The study identified clear echocardiographic evidence of myocardial dysfunction in both pediatric patients with severe malaria.
These findings confirm cardiac involvement as a manifestation of severe malaria in children.
The observed myocardial dysfunction was a significant clinical observation in these cases.

Implications:

This research highlights the importance of considering cardiac involvement in pediatric severe malaria.
Echocardiography can provide crucial diagnostic evidence of myocardial dysfunction in these children.
Early recognition and management of cardiac complications may improve outcomes for children with severe malaria.