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Updated: Jun 22, 2026

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
Published on: March 1, 2022
Modeling the entropic structural transition of DNA complexes formed with intercalating drugs
1Departamento de Física, Universidade Federal de Viçosa, CEP 36570-000, Viçosa, Minas Gerais, Brazil. marcios.rocha@ufv.br
Abstract:
A first approach is presented to explain the entropic structural transition observed in the persistence length of DNA complexes formed with intercalating drug molecules. The proposed model is based on calculating the effective persistence length of two entropic springs associated in series, one intercalated with drug molecules and the other without drugs. As the total drug concentration in the sample increases, the lengths of the two entropic springs vary, modifying the effective persistence length. The theoretical predictions of this model are then compared to experimental results, and a good accordance was obtained.
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