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Updated: Jun 22, 2026
Generation of Mice Derived from Induced Pluripotent Stem Cells
Published on: November 29, 2012
Agouti C57BL/6N embryonic stem cells for mouse genetic resources
Stephen J Pettitt1, Qi Liang, Xin Y Rairdan
1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.
Abstract:
We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation. These cells provide a robust foundation for large-scale mouse knockout programs that aim to provide a public resource of targeted mutations in the C57BL/6 genetic background.
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