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Changes in the cytokine profile and reduced function of lymphocyte subpopulations in subacute tetrachloromethane
P F Zabrodskii1, V F Kirichuk, V G Lim
1Saratov State Medical University, Russia. pz@renet.com.ru
Bulletin of Experimental Biology and Medicine
|June 16, 2009
Abstract:
Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes.
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In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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