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Specific features of the immune response in old recipient mice to cell therapy

Z S Khlystova1, I I Kalinina, S P Shmeleva

  • 1Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. morfolhum@mail.ru

Bulletin of Experimental Biology and Medicine
|June 16, 2009
PubMed

Implantation of somatic cells from autopsy specimens (15-18 weeks gestation) had a modulatory effect on immunogenesis in old mice. Activation of the immune system in recipient animals after administration of somatic cells reflects a multistage influence of test preparation. The observed changes were reversible. A progressive decrease in activation of the immune system in recipient mice was not accompanied by the development of pathological changes. Repeated implantation was required to maintain these processes.

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