Related Experiment Video
Updated: Jun 22, 2026

In Vivo Calcium Imaging of Granule Cells in the Dentate Gyrus of Hippocampus in Mice
Published on: August 2, 2024
Glycinergic inhibition in the hippocampus
1Department of Cellular and Systems Neurobiology, Max Planck-Institute of Neurobiology, Martinsried, Germany. keck@neuro.mpg.de
Abstract:
Glycine and GABA are the two main inhibitory neurotransmitters in the central nervous system (CNS). While GABA receptors in the hippocampus have been studied in great detail, the role of glycine receptors (GlyRs) in the hippocampus is less understood. Here we examine recent evidence suggesting that GlyRs are present and active throughout the hippocampus. Extracellular glycine levels are controlled through a combination of release and transport mechanisms, both of which, along with the GlyRs themselves, can be modulated by a number of factors. We discuss the role of GlyRs in suppressing excitation by decreasing postsynaptic membrane resistance in the hippocampus, as well as the contribution of GlyRs to both short- and long-term plasticity.
More Related Videos
07:51Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
Published on: November 14, 2014
08:04Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
Published on: June 6, 2025
Related Concept Videos
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Role of Hippocampus in Memory
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Excitatory and Inhibitory Effects of Neurotransmitters