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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Lateralization01:28

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...

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Related Experiment Video

Updated: Jun 22, 2026

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

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Published on: July 31, 2019

Abnormal brain lateralization and connectivity in schizophrenia.

Michele Ribolsi1, Giacomo Koch, Valentina Magni

  • 1Clinica Psichiatrica, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy.

Reviews in the Neurosciences
|June 17, 2009
PubMed
Summary

Schizophrenia involves altered brain networks, leading to reduced brain lateralization and impaired connectivity. This review examines how these network changes contribute to the disorder's complex symptoms and pathophysiology.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Schizophrenia is a complex mental disorder with symptoms including thought disturbances, hallucinations, and cognitive decline.
  • Historically, research focused on specific brain lesions, but recent evidence highlights network alterations.
  • Abnormal brain asymmetry and connectivity are increasingly recognized as key factors in schizophrenia.

Purpose of the Study:

  • To critically review current research on brain network alterations in schizophrenia.
  • To explore the role of abnormal brain asymmetry and connectivity in schizophrenia pathophysiology.
  • To synthesize findings on reduced brain lateralization and altered cortical connectivity.

Main Methods:

  • Literature review of neuroimaging and clinical studies.
  • Analysis of data on brain lateralization and functional connectivity.
  • Critical evaluation of existing contributions to the field.

Main Results:

  • Schizophrenia is associated with reduced brain lateralization, impacting left hemisphere dominance.
  • Altered connectivity among distinct cortical areas is a consistent finding.
  • Network dysfunctions are crucial determinants of schizophrenia's complex symptomatology.

Conclusions:

  • Network alterations, including abnormal asymmetry and connectivity, are central to schizophrenia.
  • Understanding these network changes is vital for advancing schizophrenia research and treatment.
  • Future research should continue to explore these network-level disruptions.