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Updated: Jun 22, 2026
Extraction of Plant-based Capsules for Microencapsulation Applications
Published on: November 9, 2016
[Extraction of lobetyolin from codonopsis with supercritical CO2]
Tongju Liu1, Shufen Li, Jiang Min
1Key Laboratory for Green Chemical Technology of State Education Ministry, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Objective:
To develop a green and rapid method for extraction of lobetyolin from C. pilosula.
Method:
Extraction of lobetyolin from C. pilosula with supercritical carbon dioxide in the presence of ethanol was studied. The effects of pressure, temperature, volume of cosolvent and extraction time on efficiency and their interactive relationships were discussed, based on central composite design and response surface methodology (RSM).
Result:
The key effect factor was volume of cosolvent. The extraction yield of lobetyolin was 0.078 6 mg x g(-1) when C. pilosula (40-60 mesh) was extracted at 30 MPa, 60 degrees C and 2 L x min(-1) (as CO2 in normal pressure and temperature) for 100 minutes with supercritical CO2 and 1 mL x min(-1) ethanol as dynamic cosolvent.
Conclusion:
This result is better than that obtained from traditional method. Therefore, the optimized process is valuable for extraction of lobetyolin from C. pilosula.
