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Updated: Jun 22, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks (MOFs)
Published on: January 17, 2020
Brønsted base/Lewis acid cooperative catalysis in the enantioselective Conia-ene reaction
Ting Yang1, Alessandro Ferrali, Filippo Sladojevich
1School of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Abstract:
A mutually compatible and cooperative combination of copper(I) triflate and bifunctional 9-amino-9-deoxyepicinchona-derived urea compounds for the enantioselective Conia-ene cyclization of alkyne-tethered beta-ketoester substrates is reported. The reaction is efficient, broad in scope, and easy to perform and allows access to chiral methylenecyclopentane products with high enantiocontrol. The transformation illustrates the concept of combining inactive precatalysts with inactive transition-metal-ion complexes in situ to reversibly create a catalytically active combination of the two.
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