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Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
Published on: February 10, 2023
IC51 Japanese encephalitis vaccine
Herwig Kollaritsch1, Maria Paulke-Korinek, Katrin Dubischar-Kastner
1Medical University Vienna, Centre for Physiology and Pathophysiology, Institute of Specific Prophylaxis and Tropical Medicine, Kinderspitalgasse 15, A-1090 Vienna, Austria. herwig.kollaritsch@meduniwien.ac.at
Japanese encephalitis is a significant Asian viral encephalitis. A new inactivated whole-virus vaccine, IXIARO, shows promise for active immunization, addressing potential vaccine shortages.
Area of Science:
- Medical Virology
- Vaccinology
- Epidemiology
Background:
- Japanese encephalitis (JE) is a leading cause of viral encephalitis in Asia, with high morbidity and mortality.
- No effective antiviral treatments exist for this mosquito-borne flavivirus.
- The discontinuation of the JE-VAX vaccine has created a potential shortage of available immunizations.
Purpose of the Study:
- To evaluate a new inactivated whole-virus vaccine candidate, IXIARO (Strain SA(14)-14-2), for active immunization against Japanese encephalitis.
- To assess the immunogenicity and tolerability of the IXIARO vaccine.
Main Methods:
- Phase III clinical trials were conducted to assess the vaccine's efficacy.
- Immunogenicity and tolerability data were collected and analyzed.
Main Results:
- The IXIARO vaccine demonstrated successful immunogenicity and tolerability in Phase III studies.
- The vaccine is considered an acceptable approach for active immunization against Japanese encephalitis.
Conclusions:
- The inactivated whole-virus vaccine IXIARO represents a promising new option for Japanese encephalitis prevention.
- Cell-culture-based vaccines like IXIARO are expected to be crucial for populations in endemic areas, travelers, and military personnel.
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