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Updated: Jun 22, 2026

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
Proteomics in protein misfolding diseases
Monica Stoppini1, Laura Obici, Francesca Lavatelli
1Department of Biochemistry, University of Pavia, Pavia, Italy.
Abstract:
Protein misfolding and deposition as amyloid, with consequent tissue damage, plays a key role in the group of diseases generically termed amyloidoses. In the systemic forms, amyloid deposition is widespread and causes severe dysfunction of vital organs. Proteomic analysis, thanks to its versatility and the comprehensiveness of information obtained, is an ideal tool for the study of systemic amyloidoses. It has been successfully employed in the characterization of the circulating amyloidogenic precursors and the analysis of affected tissues, for the diagnostic identification of the fibril components and for characterizing disease-related changes in protein expression. We present the developments in the field of proteomics applied to systemic amyloidoses, and discuss the perspectives opened in the study of these diseases.
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