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Updated: Jun 22, 2026
11:42
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
Published on: November 4, 2019
HLA-G expression is up-regulated by progesterone in mesenchymal stem cells
Ekaterina Ivanova-Todorova1, Milena Mourdjeva, Dobroslav Kyurkchiev
1Laboratory of Clinical Immunology, University Hospital St.I.Rilski, Medical University Sofia, Sofia, Bulgaria.
Summary
Progesterone enhances the expression of Human Leukocyte Antigen (HLA)-G in mesenchymal stem cells (MSCs). This finding reveals MSCs as progesterone targets and highlights HLA-G
Area of Science:
- Reproductive immunology
- Stem cell biology
- Immunomodulation
Background:
- Pregnancy involves maternal immune adaptation to fetal tissues.
- Human Leukocyte Antigen (HLA)-G, progesterone, and mesenchymal stem cells (MSCs) are known immunomodulators.
- Interactions between these factors in pregnancy are not fully understood.
Purpose of the Study:
- To investigate the effect of progesterone on HLA-G expression in MSCs.
- To explore the role of MSCs as potential targets of progesterone in regulating maternal-fetal immune balance.
Main Methods:
- Isolation of human MSCs from adipose tissue, bone marrow, and decidua.
- Culture of MSCs in the presence of progesterone.
- Quantification of HLA-G expression at both protein and mRNA levels.
Main Results:
- MSCs cultured with progesterone showed significantly increased levels of cell surface and cytoplasmic HLA-G compared to controls.
- Progesterone treatment up-regulates HLA-G expression in MSCs.
Conclusions:
- Progesterone stimulates HLA-G expression in MSCs, suggesting a novel mechanism for immune regulation during pregnancy.
- MSCs are identified as new targets of progesterone, possessing significant immunomodulatory capabilities crucial for maintaining maternal-fetal tolerance.
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