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Updated: Jun 22, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Critical inquiry and knowledge translation: exploring compatibilities and tensions.
Sheryl Reimer-Kirkham1, Colleen Varcoe, Annette J Browne
1School of Nursing, TrinityWestern University, 7600 Glover Road, Langley, British Columbia V2Y 1Y1, Canada. sheryl.kirkham@twu.ca
Knowledge translation can integrate critical knowledge on social justice and health inequities into practice. Reconciling critical inquiry with knowledge translation challenges traditional approaches, promoting a reconceptualized understanding.
Area of Science:
- Health Services Research
- Social Sciences in Health
Background:
- Knowledge translation (KT) facilitates research uptake in healthcare.
- Critically oriented knowledge addresses social justice, health inequities, and cultural safety.
- Integrating these critical perspectives into clinical practice presents unique challenges.
Purpose of the Study:
- To philosophically examine knowledge translation as a vehicle for critically oriented knowledge.
- To identify compatibilities and discrepancies between critical inquiry and knowledge translation.
- To reconceptualize knowledge translation through the lens of critical perspectives.
Main Methods:
- Philosophical examination of knowledge translation and critical inquiry traditions.
- Analysis of ontological and epistemological origins of knowledge.
- Review of the history of critical inquiry to identify common purposes.
Main Results:
- Reconciling differences within critical traditions is necessary for synthesizing knowledge.
- The critical stance of critique can be problematic in collaborative knowledge translation.
- There is a persistent pull towards positivist paradigms within knowledge translation.
Conclusions:
- Knowledge translation can be a vehicle for critical knowledge, but requires careful navigation of epistemological and methodological tensions.
- Understanding the origins of knowledge is crucial for effective synthesis and translation.
- Productive tensions arise when integrating critical inquiry with knowledge translation, leading to reconceptualization.
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