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Updated: Jun 22, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Decreased factor XIII activity in a patient with subcutaneous bleeding after double filtration plasmapheresis
Mariko Seishima1, Yoshinao Shibuya, Genichi Kato
1Department of Dermatology, Ogaki Municipal Hospital, Minaminokawa-cho 4-86, Ogaki, Japan. marikoseishima@yahoo.co.jp
Abstract:
Double filtration plasmapheresis (DFPP) is often performed as a treatment for autoimmune diseases including pemphigus vulgaris. We report a pemphigus vulgaris patient with subcutaneous bleeding, gradually spreading over a period of 10 days after DFPP. In this patient, factor XIII activity was markedly decreased. In three other patients, factor XIII activities were markedly reduced the day following DFPP, were but restored by days 7-10. From these findings, subcutaneous bleeding may have occurred in the present patient due to a delayed recovery of the decreased factor XIII activity after DFPP. Therefore, decreased factor XIII activity could be a critical cause of subcutaneous bleeding after DFPP.
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