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Trenbolone: application of the Ames test. Recent data

D Marzin1

  • 1Laboratoire de Toxicologie, Institut Pasteur de Lille, France.

Annales De Recherches Veterinaires. Annals of Veterinary Research
|January 1, 1991
PubMed

Insights

Trenbolone, a synthetic androgen, was evaluated for mutagenicity. Studies found trenbolone to be devoid of genotoxic activity, with initial positive results attributed to impurities.

Area of Science:

  • Toxicology
  • Genetics
  • Pharmacology

Background:

  • Trenbolone is a synthetic androgen with anabolic properties.
  • Assessing the genotoxicity of trenbolone is crucial for understanding its safety profile.

Purpose of the Study:

  • To comprehensively evaluate the mutagenicity and genotoxicity of trenbolone.
  • To determine if trenbolone poses a risk for genetic damage.

Main Methods:

  • Conducted a battery of in vitro and in vivo genotoxicity assays.
  • Included tests for gene mutations, chromosomal aberrations, and primary DNA damage.
  • Utilized various cell lines (SHE, C3H, CHO) and the Ames test.

Main Results:

  • Most genotoxicity tests were negative.
  • Two tests showed equivocal or positive results: the in vitro micronucleus test in SHE cells and one Ames test instance.
  • Re-testing with pure trenbolone yielded negative results, indicating initial findings were likely due to impurities.

Conclusions:

  • Trenbolone is considered devoid of genotoxic activity.
  • The genotoxicity observed in initial studies was likely attributable to impurities, not trenbolone itself.

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