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Trenbolone: application of the Ames test. Recent data.
1Laboratoire de Toxicologie, Institut Pasteur de Lille, France.
Annales De Recherches Veterinaires. Annals of Veterinary Research
|January 1, 1991
Summary
Trenbolone, a synthetic androgen, was evaluated for mutagenicity. Studies found trenbolone to be devoid of genotoxic activity, with initial positive results attributed to impurities.
Area of Science:
- Toxicology
- Genetics
- Pharmacology
Background:
- Trenbolone is a synthetic androgen with anabolic properties.
- Assessing the genotoxicity of trenbolone is crucial for understanding its safety profile.
Purpose of the Study:
- To comprehensively evaluate the mutagenicity and genotoxicity of trenbolone.
- To determine if trenbolone poses a risk for genetic damage.
Main Methods:
- Conducted a battery of in vitro and in vivo genotoxicity assays.
- Included tests for gene mutations, chromosomal aberrations, and primary DNA damage.
- Utilized various cell lines (SHE, C3H, CHO) and the Ames test.
Main Results:
- Most genotoxicity tests were negative.
- Two tests showed equivocal or positive results: the in vitro micronucleus test in SHE cells and one Ames test instance.
- Re-testing with pure trenbolone yielded negative results, indicating initial findings were likely due to impurities.
Conclusions:
- Trenbolone is considered devoid of genotoxic activity.
- The genotoxicity observed in initial studies was likely attributable to impurities, not trenbolone itself.