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Related Experiment Video

Updated: Jun 22, 2026

Micropatterning and Assembly of 3D Microvessels

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

[Endothelial cell-cell junctions in vessel formation].

Philippe Huber¹

¹Laboratoire de Physiopathologies Vasculaires, Unité CEA - Inserm - Université Joseph Fourier, CEA-Grenoble iRTSV-LAPV-U882, 17 rue des Martyrs, 38054 Grenoble.

Journal De La Societe De Biologie

|June 17, 2009

Summary

This summary is machine-generated.

The endothelium, a single layer of cells lining blood vessels, uses cell-adhesion proteins to control permeability and leukocyte movement. These proteins may also drive pathological angiogenesis by activating cell protrusions.

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Last Updated: Jun 22, 2026

Micropatterning and Assembly of 3D Microvessels

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Published on: September 9, 2016

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Endothelial Cell Tube Formation Assay for the In Vitro Study of Angiogenesis

Endothelial Cell Tube Formation Assay for the In Vitro Study of Angiogenesis

Published on: September 1, 2014

Area of Science:

Endothelial cell biology
Vascular cell adhesion

Context:

The endothelium forms a critical barrier within all vessel types.
Endothelial cell-cell contacts are mediated by transmembrane adhesive proteins.
These proteins are crucial for vascular homeostasis and leukocyte trafficking.

Purpose:

To elucidate the role of endothelial cell-cell junction proteins.
To investigate their involvement in vascular permeability and leukocyte transmigration.
To explore their potential function in pathological angiogenesis.

Summary:

Endothelial cells form a cobblestone monolayer with cell-cell contacts mediated by adhesive proteins.
These proteins regulate vascular permeability, leukocyte transmigration, and may activate cell protrusions.
Such activities are implicated in pathological angiogenesis and anti-angiogenic therapy targets.

Impact:

Highlights the dual role of endothelial junction proteins in normal physiology and disease.
Identifies potential therapeutic targets for anti-angiogenic strategies.
Advances understanding of vascular invasion mechanisms in pathological conditions.