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Direct Induction of Hemogenic Endothelium and Blood by Overexpression of Transcription Factors in Human Pluripotent Stem Cells
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Published on: December 3, 2015

[The bHLH TAL1 protein: a key molecule in the hematopoietic and endothelial systems]

Danièle Mathieu1

  • 1Institut de Génétique Moléculaire, CNRS-UMR 5535, Universités de Montpellier 1 et Montpellier 2, 1919 route de Mende, 34293 Montpellier Cedex 1, France. danielle.mathieu@igmn.cnrs.fr

Journal De La Societe De Biologie
|June 17, 2009
PubMed

The formation of blood cells and vascular networks occurs simultaneously during development, and both lineages remain in close association in all adult tissues. The functional setting of both systems within the embryo and their renewal during adult life are highly complex processes, and require the involvement of numerous molecular actors, the activities of which are often overlapping. Here, I review the activity of TAL-1, a basic-helix-loop-helix transcription factor, which plays a key role in the formation and functioning of both blood and endothelial systems, with a particular emphasis on recent data that associate TAL-1 with angiogenesis.

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