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Updated: Jun 22, 2026
In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium
Published on: May 6, 2018
[The surgeon and anti-angiogenics]
1INSERM U965, Institut des Vaisseaux et du Sang, Hôpital Lariboisière, Université Paris-Diderot/Paris VII, 8 rue Guy Patin, 75475 Paris Cedex 10, France. marc.pocard@1rb.aphp.fr
Abstract:
The surgeon must know the importance of angiogenesis in wound healing. He must also use anti-angiogenics to change the clinical situations and make curative a potentially ineffective surgery. However, these strategies require daily biological indicators able to quantify the tissue activity, that we do not possess yet, nor have we any indicator to predict tumour sensitivity to anti-angiogenics.
Insights
Surgeons need to understand angiogenesis in wound healing and use anti-angiogenics for better surgical outcomes. Current strategies lack daily biological indicators for tissue activity and predicting tumor response.
Area of Science:
- Vascular biology and surgical oncology.
Background:
- Angiogenesis, the formation of new blood vessels, is crucial for wound healing.
- Anti-angiogenic therapies can alter clinical situations and improve surgical outcomes for potentially ineffective procedures.
Purpose of the Study:
- To highlight the importance of angiogenesis in surgery.
- To emphasize the need for biological indicators to guide anti-angiogenic strategies.
Main Methods:
- This study reviews the role of angiogenesis and anti-angiogenics in surgical contexts.
Main Results:
- Current anti-angiogenic strategies lack reliable daily biological indicators for tissue activity.
- There are no established indicators to predict tumor sensitivity to anti-angiogenic treatments.
Conclusions:
- Effective clinical application of anti-angiogenics in surgery requires the development of new biological monitoring tools.
- Predictive markers for anti-angiogenic therapy efficacy are essential for optimizing surgical treatments.
