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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and produces two-second...
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
Introduction to Language of Pathophysiology l01:25

Introduction to Language of Pathophysiology l

Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like pain), laboratory test...
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

Published on: February 22, 2019

From pathogenesis to cell biology and back.

Serge Mostowy1, Pascale Cossart

  • 1Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, F-75015 France.

Cell Host & Microbe
|June 17, 2009
PubMed
Summary

Investigating microbial pathogenesis enhances understanding of infection and cell biology. New research and technologies offer novel insights into disease mechanisms and cellular functions.

Area of Science:

  • Infection Biology
  • Cell Biology
  • Microbial Pathogenesis

Background:

  • Understanding how microbes cause disease is crucial for both infection and cell biology.
  • Advances in knowledge of the infected cell are rapidly emerging.
  • Innovative technologies are enabling new research approaches.

Purpose of the Study:

  • To explore novel research avenues at the intersection of infection biology and cell biology.
  • To leverage improved knowledge of the infected cell for scientific advancement.
  • To identify new domains for investigating fundamental cellular processes and pathogenesis.

Main Methods:

  • Utilizing cutting-edge technologies for studying host-pathogen interactions.
  • Applying advanced cell biology techniques to analyze infected cells.

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A Web Tool for Generating High Quality Machine-readable Biological Pathways
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A Web Tool for Generating High Quality Machine-readable Biological Pathways

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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses
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Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses

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A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster
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A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

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A Web Tool for Generating High Quality Machine-readable Biological Pathways

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  • Employing molecular and genetic approaches to dissect microbial pathogenesis.

    • Main Results:

    • Identification of unique research pathways driven by microbial disease mechanisms.
    • Enhanced comprehension of cellular responses during infection.
    • Development of innovative tools for studying host-pathogen dynamics.

    Conclusions:

    • The study of microbial pathogenesis opens new frontiers in biological research.
    • Integrating infection biology and cell biology advances our understanding of disease.
    • Future investigations promise deeper insights into cellular processes and disease causation.