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Hypomelanosis of Ito: involvement of chromosome aberrations in this syndrome
E Lenzini1, P Bertoli, L Artifoni
1Servizio di Genetica Medica, Dipartimento di Pediatria, Università di Padova, Italy.
Annales De Genetique
|January 1, 1991
Abstract:
The authors report on cytogenetic results of six patients with hypomelanosis of Ito. Karyotypes from peripheral lymphocytes prometaphases and skin fibroblasts metaphases were normal. A review of the literature revealed no specific chromosomal abnormality but a close association between mosaicism and HI syndrome. The X-chromosome was involved in 53% of the abnormal cases.