Evaluating global and regional left ventricular function in patients with reperfused acute myocardial infarction by

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Ammar Sarwar1, Michael D Shapiro, Khurram Nasir

  • 1Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

Journal of Cardiovascular Computed Tomography
|June 17, 2009
PubMed

Insights

64-slice computed tomography (CT) accurately assesses left ventricular (LV) function in patients post-myocardial infarction. This study shows MDCT is a reliable alternative to cardiac MRI for evaluating global and regional LV function after reperfusion.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Previous studies compared 64-slice multidetector row computed tomography (MDCT) and cardiac magnetic resonance (CMR) for left ventricular (LV) function.
  • No prior studies evaluated these methods in patients with reperfused acute myocardial infarction.

Purpose of the Study:

  • To compare global and regional LV function assessment by 64-slice MDCT with CMR.
  • To evaluate the accuracy and reproducibility of MDCT in patients after reperfused ST-elevation myocardial infarction.

Main Methods:

  • Twenty-one patients with reperfused ST-elevation myocardial infarction underwent contrast-enhanced CMR and MDCT.
  • Global LV function (volumes, mass, ejection fraction) and regional function (17-segment model) were assessed using Simpson's method and a 4-point scale.

Main Results:

  • MDCT demonstrated good correlation with CMR for all global LV function parameters (LVEF r=0.90, LVEDV r=0.91, LVESV r=0.94, LVSV r=0.84, LV mass r=0.91).
  • Interobserver agreement for regional function was excellent and comparable between MDCT (0.86) and CMR (0.88).
  • MDCT showed high sensitivity and specificity for detecting akinetic segments compared to CMR.

Conclusions:

  • MDCT provides accurate and reproducible measurements of global and regional LV function.
  • 64-slice MDCT is a reliable imaging modality for assessing LV function in patients with reperfused acute myocardial infarction.
Abstract

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