Family data determine all parameters in Mendelian incomplete penetrance models
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A S Whittemore1, J B Keller, M J Ward
1Department of Health Research and Policy, Stanford University School of Medicine, CA 94305-5092.
Annals of Human Genetics
|May 1, 1991
Abstract:
We show that data on the frequency of occurrence of an hereditary trait in family members can be used to determine all four parameters in a Mendelian genetic model with incomplete penetrance. Thus previous statements in the literature that such data can determine only three combinations of the parameters are incorrect.