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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

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Related Experiment Video

Updated: Jun 22, 2026

Merkel Cell Polyomavirus Infection and Detection
13:45

Merkel Cell Polyomavirus Infection and Detection

Published on: February 7, 2019

A Merkel cell carcinoma treatment algorithm.

Joseph H Ruan1, Mark Reeves

  • 1Department of Surgery, Loma Linda University Medical Center, 11175 Anderson St, Ste 21108, Loma Linda, CA 92354, USA. joeruan@gmail.com

Archives of Surgery (Chicago, Ill. : 1960)
|June 17, 2009
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma, a rare skin cancer, presents unique challenges due to its aggressive nature and limited research. This study reviews cases and literature to propose a treatment algorithm for this difficult-to-manage malignancy.

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Area of Science:

  • Oncology
  • Dermatology
  • Rare Cancers

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with approximately 2000 reported cases since 1972.
  • Its rarity impedes extensive scientific study, with current knowledge primarily derived from retrospective case studies and case reports.
  • No definitive management strategy has been established despite various treatment modalities.

Purpose of the Study:

  • To demonstrate the heterogeneity of Merkel cell carcinoma through recent case presentations.
  • To review existing literature on MCC management.
  • To propose a treatment algorithm for this rare and aggressive skin cancer.

Main Methods:

  • Presentation of several recent Merkel cell carcinoma cases.
  • Comprehensive review of the scientific literature concerning MCC.
  • Development of a suggested treatment algorithm based on case data and literature.

Main Results:

  • Case studies highlighted the diverse presentations of Merkel cell carcinoma.
  • Literature review confirmed the lack of a standardized treatment approach.
  • A treatment algorithm was formulated to guide management.

Conclusions:

  • Merkel cell carcinoma exhibits significant heterogeneity, complicating treatment.
  • A structured treatment algorithm may improve the management of this rare and aggressive cancer.
  • Further research is needed to refine treatment strategies for Merkel cell carcinoma.